Muneer lab focuses on understanding the underlying mechanisms of TBI or alcohol-mediated neurovascular inflammation and neurodegeneration with the objective of developing effective therapeutic strategies to enhance recovery from TBI or alcohol mediated neurological dysfunctions. Another emphasis of the studies is to unravel the signaling mechanisms behind the constraints in neuronal regeneration in the central nervous system (CNS) after injuries. Muneer lab is highly interested in exploring inter/intracellular signaling pathways and various regulatory factors of neuronal growth in TBI. The ultimate goal of the study is to develop successful therapeutic strategies for improving recovery from TBI or TBI+alcohol-induced CNS injuries. The lab use in vivo model of alcohol abuse, the TBI-fluid percussion model, and in vitro stretch injury model to study the mechanisms and therapeutic strategies in brain injury. In addition, we employ various in vitro and in vivo research approaches, including blocking of repulsive signaling pathways using pharmacological methods, peptide therapy, virus vector-mediated gene transfer to the brain, CRISPR/Cas9 gene deletion, in vitro stretch injury, survival animal surgeries, etc.

For more details about the traumatic brain injury and spinal cord injury
 
1. NIH NINDS traumatic brain injury information