Muneer lab focuses on the molecular and cellular mechanisms underlying axonal regeneration, neuronal repair, and survival following traumatic brain injury (TBI), aiming to develop effective therapeutic strategies for neurological recovery. His research explores signaling pathways that limit neuronal regeneration in central nervous system (CNS) injury. Using in vivo fluid percussion and in vitro stretch injury models, the lab employs advanced approaches including viral vector-mediated gene transfer, CRISPR/Cas9 gene editing, conditional knockout models, pharmacological blockade of repulsive signaling, survival animal surgeries, and behavioral assessments in rodents. Additionally, Dr. Muneer investigates blood-brain barrier disruption and its role in neurovascular inflammation and neurological disorders such as stroke linked to alcohol use disorder. His current work tests the hypothesis that activation of the antioxidant Nrf2 pathway can repair alcohol-induced cerebral vascular injury, neuroinflammation, and neurodegeneration.

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For more details about the traumatic brain injury 

NIH NINDS traumatic brain injury information