Muneer Laboratory
Laboratory of CNS Injury and Molecular Therapy
Department of Biomedical Engineering
Welcome to the Muneer Laboratory
for traumatic brain injury and alcohol research
Our research focuses on developing peptide- and gene-based therapeutic strategies for traumatic brain injury (TBI) and alcohol-induced brain damage
Muneer lab focuses on the molecular and cellular mechanisms underlying axonal regeneration, neuronal repair, and survival following traumatic brain injury (TBI), aiming to develop effective therapeutic strategies for neurological recovery. His research explores signaling pathways that limit neuronal regeneration in central nervous system (CNS) injury. Using in vivo fluid percussion and in vitro stretch injury models, the lab employs advanced approaches including viral vector-mediated gene transfer, CRISPR/Cas9 gene editing, conditional knockout models, pharmacological blockade of repulsive signaling, survival animal surgeries, and behavioral assessments in rodents. Additionally, Dr. Muneer investigates blood-brain barrier disruption and its role in neurovascular inflammation and neurological disorders such as stroke linked to alcohol use disorder. His current work tests the hypothesis that activation of the antioxidant Nrf2 pathway can repair alcohol-induced cerebral vascular injury, neuroinflammation, and neurodegeneration.
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For more details about the traumatic brain injury
Dr. Mohammed Abdul Muneer is an Associate Professor in the Department of Biomedical Engineering at Florida International University, Miami, FL. He has over 20 years of experience in translational neuroscience research, with a focus on neuroimmunology, traumatic brain injury, and alcohol-induced brain damage. Dr. Muneer has authored over 50 peer-reviewed
publications in high-impact journals such as The Journal of Neuroscience, Molecular Neurodegeneration, Brain Behavior and Immunity, and eNeuro. He has secured five extramural research grants, including an NIH R01 ($2.2M) and R21 ($500k). He has experience in mentoring several postdoctoral fellows as well as high school, undergraduate, and graduate students. He serves on grant review panels for federal agencies such as the NIH and DoD. Additionally, Dr. Muneer has been serving as an Editorial Board member in different journals such as Journal of Spinal Cord Medicine, Antioxidants, Frontiers in Genetics, Trauma Cases and Reviews, JSM Brain Science; and Topical Advisory panel in ‘Antioxidants’ and is a peer reviewer for more than 25 journals.
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