Muneer Laboratory
Laboratory of CNS Injury and Molecular Therapy
Journal Publications
Full publications list in PubMed
1. Saikia BB, Bhowmick S, Malat A, Preetha Rani MR, Thaha A, Abdul-Muneer PM* (2023). ICAM-1 deletion using CRISPR/Cas9 protects the brain from traumatic brain injury-induced inflammatory leukocyte adhesion and transmigration cascades by attenuating the paxillin/FAK-dependent Rho GTPase pathway. Journal of Neuroscience (In press). *Corresponding author.
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2. Bhowmick S, Preetha Rani MR, Singh S, Abdul-Muneer PM* (2023). Discovery of novel microRNAs and their pathogenic responsive target genes in mild traumatic brain injury. Experimental Brain Research, 241(8): p. 2107-2123. *Corresponding author. https://link.springer.com/article/10.1007/s00221-023-06672-z
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3. Abdul-Muneer, P.M (2023). Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury. J Integr Neurosci, 2023. 22(4): p. 81. *Corresponding author.
https://pubmed.ncbi.nlm.nih.gov/37519172/
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4. Abdul-Muneer PM*, Saikia BB, Bhowmick S (2022). Synergistic effect of mild traumatic brain injury and alcohol exacerbates neuroinflammation, amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations: impact on psychological stress. Experimental Neurology; 358:114222. doi: 10.1016/j.expneurol.2022.114222. *Corresponding author. https://www.sciencedirect.com/science/article/abs/pii/S0014488622002473?via%3Dihub
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5. Saurav Bhowmick, Saleena Alikunju, P.M Abdul-Muneer* (2022). NADPH oxidase-induced activation of transforming growth factor-beta-1 causes neuropathy by suppressing antioxidant signaling pathways in alcohol use disorder. Neuropharmacology; DOI: 10.1016/j.neuropharm.2022.109136. *Corresponding author.
https://www.sciencedirect.com/science/article/abs/pii/S0028390822001952
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6. Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D’Mello, Christina Finn, P. M Abdul-Muneer* (2021). Intercellular adhesion molecule-1-induced post traumatic brain injury neuropathology in the prefrontal cortex and hippocampus leads to sensorimotor function deficits and psychological stress. eNeuro, ENEURO.0242-21.2021. *Corresponding author. https://www.eneuro.org/content/8/4/ENEURO.0242-21.2021
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7. Saurav Bhowmick, Abdul-Muneer PM* (2021). PTEN blocking stimulates corticospinal and raphespinal axonal regeneration and promotes functional recovery after spinal cord injury. Journal of Neuropathology and Experimental Neurology, 80(2): 169-181. Corresponding author.
https://pubmed.ncbi.nlm.nih.gov/33367790/
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8. Saurav Bhowmick, Veera D’Mello, Danielle Caruso, Abdul-Muneer PM* (2019). Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. Journal of Molecular Medicine (Berl), 97(12): 1627-1641. Corresponding author.
​ https://pubmed.ncbi.nlm.nih.gov/31758217/
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9. Saurav Bhowmick, Veera D’Mello, Alex Wallerstein, Danielle Caruso, Abdul-Muneer PM* (2019). Impairment of endothelial cell-pericyte cross talk leads to blood-brain barrier damage following traumatic brain injury. Experimental Neurology, 317: 260-270. Corresponding author. https://www.ncbi.nlm.nih.gov/pubmed/30926390
10. Saurav Bhowmick, Veera D’Mello, Abdul-Muneer PM* (2018). Synergistic inhibition of ERK1/2 and JNK, not p38, phosphorylation ameliorates neuronal damages after traumatic brain injury. Molecular Neurobiology, doi.org/10.1007/s12035-018-1132-7. Corresponding author.
https://www.ncbi.nlm.nih.gov/pubmed/29873042
11. Saurav Bhowmick, Veera D’Mello, Abdul-Muneer PM* (2018). Neurodegeneration and sensorimotor deficits in the mouse model of traumatic brain injury. Brain Sciences, 2018 Jan 6;8(1). pii: E11. doi: 10.3390/brainsci8010011. Corresponding author. https://www.ncbi.nlm.nih.gov/pubmed/29316623.
12. Abdul-Muneer PM*, Saurav Bhowmick, Nicholas Briski (2017). Angiotensin II causes neuronal damage in stretch injured neurons: protective effects of losartan, an angiotensin II type 1 receptor antagonist. Molecular Neurobiology, doi: 10.1007/s12035-017-0812-z. Corresponding author.
https://www.ncbi.nlm.nih.gov/pubmed/29119534
13. Abdul Muneer PM, Alikunju S, Schuetz H, Szlachetka AM, Ma X, and Haorah J (2017). Impairment of Thiamine Transport at the GUT-BBB-axis Contributes to Wernicke Encephalopathy. Molecular Neurobiology; doi: 10.1007/s12035-017-08110.
https://www.ncbi.nlm.nih.gov/pubmed/29128903
14. Patel RK, Prasad N, Kuwar R, Haldar D, Abdul-Muneer PM* (2017). Transforming growth factor-beta1 signaling regulates neuroinflammation and apoptosis in mild traumatic brain injury. Brain Behavior and Immunity, doi:10.1016/j.bbi.2017.04.012. Corresponding author. https://www.ncbi.nlm.nih.gov/pubmed/28433746
15. Abdul-Muneer PM, Alikunju S, Mishra V, Schuetz H, Szlachetka AM, Burnham EL, Haorah J (2017). Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. Brain Behavior and Immunity, doi:10.1016/j.bbi.2017.02.014. https://www.ncbi.nlm.nih.gov/pubmed/28232172
16. Ohtake Y, Wong D, Abdul-Muneer PM, Selzer ME, Li S* (2016). Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons. Scientific reports, 6:37152. doi: 10.1038/srep37152. https://www.ncbi.nlm.nih.gov/pubmed/27849007
17. Abdul-Muneer PM*, Conte AA, Haldar D, Long M, Santhakumar V, Overall CM, Pfister BJ (2016). Traumatic brain injury induced matrix metalloproteinase-2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Brain, Behavior and Immunity, http://dx.doi.org/10.1016/j.bbi.2016.09.002. *Corresponding author. https://www.ncbi.nlm.nih.gov/pubmed/27614125
18. Abdul Muneer PM*, Long M, Conte AA, Santhakumar V, Pfister BJ (2016). High Ca2+ influx during traumatic brain injury leads to caspase-1 dependent neuroinflammation and cell death. Molecular Neurobiology. DOI: 10.1007/s12035-016-9949-4. *Corresponding author. https://www.ncbi.nlm.nih.gov/pubmed/27289225
19. Abdul Muneer PM* (2016). MicroRNA in the pathophysiology of CNS injury: implication in neuroregenerative medicine. CNS Neuroscience and therapeutics, 22(7):543-545. Corresponding author.
20. Abdul-Muneer PM*, Pfister BJ, Haorah J, Chandra N (2015). Role of matrix metalloproteinases in the pathogenesis of traumatic brain injury and other neurological diseases. Molecular Neurobiology, 10.1007/s12035-015-9520-8. Review manuscript. Corresponding author.
21. Zhang G, Zhao H, Abdul Muneer PM, Cao H, Li X and Geller AI* (2014). Neurons can be labeled with unique hues by helper virus-free HSV-1 vectors expressing brainbow. J Neuroscience methods, doi.org/10.1016/j.jneumeth.2014.11.009.
22. Abdul Muneer PM*, Chandra N, Haorah J (2014). Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of secondary mild traumatic brain injury. Molecular Neurobiology, 51(3):966-979. Review manuscript. *Corresponding author.
23. Otake Y, Park D, Abdul Muneer PM, Li H, Xu B, Sharma K, Smith GM, Selzer ME and Li S (2014). The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury. Biomaterials, 35(16):4610-4626.
24. Abdul Muneer PM, Schueltz H, Wang F, Skotak M, Jones J, Gorantla S, Zimmerman MC, Chandra N and Haorah J (2013). Induction of Oxidative and Nitrosative damage leads to Cerebrovascular Inflammation in Animal Model of Mild Traumatic Brain Injury Induced by Primary Blast. Free Radical Biology and Medicine; 60(2013)282–291.
25. Li H, Park D, Abdul Muneer PM, Xu B, Wang H, Xing B, Wu D and Li S (2013). PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience; 253:89-99.
26. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2012). The Mechanisms of Cerebral Vascular Dysfunction and Neuroinflammation by MMP-mediated Degradation of VEGFR-2 in Alcohol Ingestion. Arteriosclerosis, Thrombosis and Vascular Biology; 32: 1167-1177.
27. Alikunju S*, Abdul Muneer PM*, Zhang Y, Szlachetka AM, and Haorah J (2011). The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components. Brain Behavior and Immunity, 25 Suppl 1:S129-36. *Joint-first authors.
28. Rump TJ, Abdul Muneer PM, Szlachetka AM, Lamb A, Haorei C, Alikunju S, Xiong H, Keblesh J, Liu J, Zimmerman MC, Jones J, and Haorah J (2010). Acetyl-L-carnitine Protects Neuronal Function from Alcohol-induced Oxidative Damage in the Brain. Free Radical Biology and Medicine, 49(10): 1494-1504.
29. Abdul Muneer PM*, Alikunju S*, Szlachetka AM, and Haorah J (2011). Methamphetamine Inhibits Glucose Uptake by Human Astrocytes and Neurons: Stabilization by Acetyl-L-carnitine. PLoS ONE, 6(4): e19258. *Joint-first authors.
30. Abdul Muneer PM, Alikunju S, Szlachetka AM, Murrin CL, and Haorah J (2011). Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction. Molecular Neurodegeneration, 6:23. Highly accessed.
31. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2011). Inhibitory effects of alcohol on glucose transport across the blood–brain barrier leads to neurodegeneration: preventive role of acetyl-L-carnitine. Psychopharmacology. 214(3): 707-718.
32. Abdul Muneer PM, Alikunju S, Szlachetka AM, and Haorah J (2011). Ethanol impairs glucose uptake by human astrocytes and neurons: protective effects of acetyl-L-carnitine. Int J Physiol Pathophysiol Pharmacol. 2011; 3(1): 48-56.